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appearance and Topography of Integrins and Basement Membrane Proteins in Epidermal Carcinomas: Basal but not Squamous Cell Carcinomas Display lack of 64 and BM600/Nicein
Paola Savoia1, Livio Trusolino1, Eugenio Pepino2, Ottavio Cremona1 and Pier Carlo Marchisio1Top of pageAbstractThe reflection and topography of some integrins and basement membrane proteins in cutaneous basal cell carcinomas (BCCs) And squamous wireless carcinomas (SCCs) being studied by immunohistochemistry and Western blotting. It has been confirmed that the typical celltocell distribution of 21 and 31 found in normal epidermis is replaced by pericellular distribution in both BCC and SCC cells. BCC and SCC also showed different patterns of terms of 64, An integrin heterodimer normally lining the basal surface of basal epidermis keratinocytes: Whereas SCC showed high expression and pericellular syndication of 64, BCC cells did not think this integrin at all. the lack of 6 and 4, Subunits from BCC extracts was revealed by Western blotting. The molecular arrangement of the basement membrane was markedly different in the two types of epidermal tumors. Whereas laminin and collagen type IV were conserved in the basement membrane zone of both tumors, The molecular structure BM600/nicein, Which is recognized oakleys by the monoclonal antibody GB3 and is possibly identical to the previously described basement membrane glycoproteins kalinin and epiligrin, Was lacking from BCC cells. subsequently, The multiple loss of expression of 64, And BM600/nicein in BCC cells but not in SCC cells indicates that 64 integrin and one of its potential ligands may be coregulated in both BCC and SCC, Thus implying a role for this phenomenon in the pathogenesis and clinical behavior of these epidermal tumors.
appearance and Topography of Integrins and Basement oakleys glasses Membrane Proteins in Epidermal Carcinomas


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